Bone marrow transplantation demonstrates medullar origin of CD34+ fibrocytes and ameliorates hepatic fibrosis in Abcb4-/- mice.

Martin Roderfeld,Timo Rath,Robert Voswinckel,Christian Dierkes,Hartmut Dietrich,Daniel Zahner,Jürgen Graf,Elke Roeb

Hepatology (Baltimore, Md.)（2010）

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摘要

The present study is the first to identify that both BM-derived fibrocytes and HSC are involved in biliary fibrogenesis in Abcb4(-/-) mice. Our data suggest that changes in immunity subsequent to BM-Tx may alter hepatic fibrosis.

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