Arylsulfonamide pyrimidines as VLA-4 antagonists.

Bioorganic & Medicinal Chemistry Letters（2013）

引用 5|浏览12

暂无评分

摘要

A series of (S)-2-(2-(diethylamino)-5-(N-alkyl-N-sulfonamido)pyrimidin-4-ylamino)-3-(4-(carbamoyloxy)phenyl)propanoic acid is discovered as orally available VLA-4 antagonists. Representative compounds 11b and 11p showed efficacy in multiple in vivo animal models. The in vitro selectivity of 11p is also described.

查看译文

关键词

α4β1,VLA-4,Antagonist,Orally available,CIA model,EAE model

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要