The role of DNA hypomethylation, histone acetylation and in vivo protein-DNA binding in Epstein-Barr virus-induced CD23 upregulation.

Kalman Szenthe,Anita Koroknai,Ferenc Banati,Zoltan Bathori,Hans Helmut Niller,Hans Wolf,Noemi Nagy,Eva Klein,Janos Minarovits,Daniel Salamon

Biochemical and Biophysical Research Communications（2013）

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摘要

•DNA methylation is not a major regulator of EBV-induced CD23 transcription.•High level CD23 associates with wide hypomethylated area in CD23 regulatory regions.•Levels of AcH3 at the CD23b promoter correlate with the levels of CD23b mRNA.•No sign of in vivo protein-DNA interactions at the CBF1 site.•No sign of in vivo protein-DNA interactions at the intronic EBV-responsive enhancer.

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关键词

AcH3,BL,CBF1,ChIP,Cp,DMS,EBNA,EBV,IEBVRE,LCL,LMP,LMP2Ap,LM-PCR,PCR,TIC

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