Thrombin-sensitive expression of the store operated Ca(2+) channel Orai1 in platelets.

•In blood platelets, thrombin upregulates protein abundance of Ca2+ channel Orai1.•The effect is paralleled by transient formation of mRNA from pre-RNA.•The effect is blunted by inhibition of translation but not by inhibition of transcription.•The effect is blunted by pharmacological inhibition of phosphoinositide-3-kinase.