The discovery of potent selective NPY Y(2) antagonists.

Wenying Chai,Victoria D Wong,Diane Nepomuceno,Pascal Bonaventure,Timothy W Lovenberg,Nicholas I Carruthers

Bioorganic & medicinal chemistry letters（2013）

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摘要

A series of small molecules with a piperidinyl core were synthesized and tested for binding affinity (IC50) at human Neuropeptide Y Y2 receptor. Various amide related analogs (ureas, reversed amides, and sulfonamides) were evaluated. Several potent and selective NPY Y2 antagonists were identified.

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