Biodegradable multiblock poly(N-2-hydroxypropyl)methacrylamide gemcitabine and paclitaxel conjugates for ovarian cancer cell combination treatment.

Nate Larson,Jiyuan Yang,Abhijit Ray,Darwin L Cheney,Hamidreza Ghandehari,Jindřich Kopeček

International Journal of Pharmaceutics（2013）

引用 50|浏览5

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摘要

•Synthesis of degradable multiblock polymeric nanomedicines.•Cytotoxicity of combination treatments determined by combination index analysis.•Sequential addition of nanomedicines to A2780 cells has an impact on cytotoxicity.•Two nanomedicines are more cytotoxic than a nanomedicine containing both drugs.

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关键词

HPMA copolymers,Biodegradable polymers,Combination therapy,Ovarian cancer,Gemcitabine,Paclitaxel

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