Proteostasis of polyglutamine varies among neurons and predicts neurodegeneration

Andrey S Tsvetkov,Montserrat Arrasate,Sami Barmada,D Michael Ando,Punita Sharma,Benjamin A Shaby,Steven Finkbeiner

Nature chemical biology（2013）

引用 153|浏览6

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摘要

Monitoring the half-life of mutant huntingtin protein reveals how specific neurons are more susceptible to its toxic effects and to Huntington's disease.

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nature chemical biology, science

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