The MFS-type efflux pump Flr1 induced by Yap1 promotes canthin-6-one resistance in yeast.

Camille Dejos,Matthieu Régnacq,Marianne Bernard,Pierre Voisin,Thierry Bergès

FEBS Letters（2013）

引用 9|浏览3

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摘要

•Overexpression of the transcription factor-drug transporter pair Yap1–Flr1 increase yeast resistance to canthin-6-one.•Canthin-6-one resistance mediated by Flr1 is strictly dependent on YAP1.•Glutathione and N-acetyl-cysteine rescue yeast from the cytotoxic effects of canthin-6-one.

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关键词

Saccharomyces cerevisiae,Canthin-6-one resistance,Transcription factor,Membrane efflux pump

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