A prospective, randomized, double-blind, multicenter comparative study on the safety and efficacy of Celecoxib and GCSB-5, dried extracts of six herbs, for the treatment of osteoarthritis of knee joint.

Yong-Geun Park,Chul-Won Ha,Chang-Dong Han,Seong-Il Bin,Hee-Chun Kim,Young-Bok Jung,Hong-Chul Lim

Journal of Ethnopharmacology（2013）

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摘要

Regarding the difference of the change in total WOMAC score between the two groups (the GCSB-5 group minus the Celecoxibgroup), upper one-sided 97.5% confidence limits did not exceed the pre-specified inferiority clinical margin of 9. •: GCSB-5 300mg, ○: GCSB-5 placebo, ◆: Celecoxib200mg, ◊: Celecoxibplacebo

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ADR,AE,COX-1,COX-2 inhibitor,FDA,GEE,ITT,IL-1beta,K/L,LOCF,MCID,NSAIDs,OA,PP,PGI2,SD,PGART,TXA2,TNF-α,VAS,WOMAC

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