H-2 S region determined polymorphic variants of the C4, Slp, C2, and B complement proteins: a compilation.

Until approximately 5 years ago, the murine complement system had largely been neglected, and most of the advances in the understanding of the structure-function relationships of the proteins of the complement pathways have been derived from studies with human and guinea pig proteins. The demonstration in the early 1970's that the mouse serum substance (Ss) protein was the homologue of the fourth component of human complement (C4) (reviewed by Shreffler 1976, Shreffler 1981, Shreffler et al. 1981) and the finding that the structural genes for C4, the second component of complement (C2), and a component of the alternative pathway (B), were in the human leukocyte antigen (HLA) complex markedly increased the interest in this area (reviewed by Alper 1981).