Thiazoles and thiopyridines: novel series of high affinity h5HT(7) ligands.

Christopher G Thomson,Margaret S Beer,Neil R Curtis, Helen J Diggle, Emma Handford,Janusz J Kulagowski

Bioorganic & medicinal chemistry letters（2004）

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摘要

A series of thiazole based 5HT(7) ligands has been identified from screening. Optimisation of the pendent aryl group and modification of the core gave a related series of high affinity, selective thiopyridine based 5HT(7) ligands, the most active of which behaves as a partial agonist.

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