[Schistosoma japonicum: screening of cDNA library with sera from self-cured water buffaloes (Bos buffelus)].
Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases(2003)
摘要
OBJECTIVE:To understand and identify the molecules related to the self-cure of Schistosoma japonicum infection in water buffaloes.
METHODS:The S. japonicum adult worm cDNA library was immunologically screened with the sera of self-cured water buffaloes. The positive clones were identified, cloned, sequenced and analysed with software.
RESULTS:Three genes encoding antigens relevant to sera antibodies in water buffaloes were cloned and sequenced. These antigens included paramyosin (Sj97), GST, carbonyl reductase-like 20-beta-hydroxysteroid dehydrogenase(CR/20-beta-HSD).
CONCLUSION:Sera from self-cured S. japonicum infected water buffaloes can be used to screen adult worm cDNA library for vaccine development.
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