Discovery of oral and inhaled PDE4 inhibitors.

Pauline C Ting,Joe F Lee,Rongze Kuang,Jianhua Cao,Danlin Gu,Ying Huang,Zhidan Liu,Robert G Aslanian,Kung-I Feng,Daniel Prelusky,James Lamca,Aileen House,Jonathan E Phillips,Peng Wang,Ping Wu,Daniel Lundell,Richard W Chapman,Chander S Celly

Bioorganic & Medicinal Chemistry Letters（2013）

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摘要

The optimization of oxazole-based PDE4 inhibitor 1 has led to the identification of both oral (compound 16) and inhaled (compound 34) PDE4 inhibitors. Selectivity against PDE10/PDE11, off target screening, and in vivo activity in the rat are discussed.

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关键词

PDE4 inhibitor,Asthma,COPD

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