Receptor for advanced glycation end-products (RAGE) activates divergent signaling pathways to augment neurite outgrowth of adult sensory neurons.
Experimental Neurology(2013)
摘要
•RAGE ligands significantly elevated neurite outgrowth in adult sensory neurons.•RAGE ligands signal through NF-κB, ERK and Stat3 pathway.•Function blocking antibody to RAGE inhibits neurite outgrowth driven by RAGE ligands.•RAGE ligands induced a rapid elevation of NF-κB p65 subunit gene expression.•RAGE ligands increase staining for NF-κB p50 subunit in the nucleus.•Lentivirus carrying shRNA to RAGE or to NF-κB p50 blocks neurite outgrowth.
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关键词
Neurotrophic factor,Axon regeneration,NF-kappaB,Human glycated albumin,Lentiviral shRNA,JAK/STAT,Signal transduction
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