Synthesis and biological evaluation of novel C-aryl d-glucofuranosides as sodium-dependent glucose co-transporter 2 inhibitors.

Tzung-Sheng Lin,Ya-Wen Liw,Jen-Shin Song,Tsung-Chih Hsieh,Hsien-Wei Yeh,Lih-Ching Hsu,Chun-Jung Lin,Szu-Huei Wu,Pi-Hui Liang

Bioorganic & Medicinal Chemistry（2013）

引用 13|浏览22

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摘要

Novel C-aryl-d-glucofuranosides were synthesized and evaluated for their capacity to inhibit human sodium-dependent glucose co-transporter 2 (hSGLT2) and hSGLT1. Compound 21q demonstrated the best in vitro inhibitory activity against SGLT2 in this series (EC50=0.62μM).

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关键词

Antidiabetics,SGLT,Glucofuranosides

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