Periostin inhibits hypoxia-induced apoptosis in human periodontal ligament cells via TGF-β signaling.

Paveenarat Aukkarasongsup,Naoto Haruyama,Tsutomu Matsumoto,Momotoshi Shiga,Keiji Moriyama

Biochemical and Biophysical Research Communications（2013）

引用 31|浏览5

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摘要

•Hypoxia induces human periodontal ligament cell apoptosis.•Periostin siRNA increases HIF-1α protein, but decreases PHD2 mRNA, in hypoxic cells.•Periostin increases PHD2 mRNA, but decreases HIF-1α protein, in hypoxic cells.•Periostin inhibits TGF-β1/SMAD2 signaling under hypoxic conditions.•Periostin inhibits hypoxia-induced apoptosis in human periodontal ligament cells.

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关键词

Periostin,Apoptosis,HIF-1α,Periodontal ligament,TGF-β1,Hypoxia

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