Brca Mutations And Outcome In Epithelial Ovarian Cancer (Eoc): Experience In Ethnically Diverse Groups

Variation in the worldwide prevalence of BRCA1 and BRCA2 mutations is well recognized. We analyzed BRCA mutation type variability in 585 BRCA-tested epithelial ovarian cancer patients from different ethnic populations. Of these patients, 98 (16.8%) were carriers of the BRCA1 mutation, and 34 (5.8%) were carriers of BRCA2. Among the BRCA1/2 carriers, there were 29 mutation types. The widest variation in mutation types was in non-Jewish Caucasians. Our analysis showed statistically improved overall survival and a tendency towards improved first progression-free survival across all BRCA mutation subtypes, compared to non-carriers.