Utility of a Commercial PCR Assay and a Clinical Prediction Rule for Detection of Toxigenic Clostridium Difficile in Asymptomatic Carriers

Curtis J. Donskey,Venkata C. K. Sunkesula,Annette L. Jencson,Nimalie D. Stone,Carolyn V. Gould,L. Clifford McDonald,Matthew Samore,Jeanmarie Mayer,Susan Pacheco,Susan Sambol,Laurica Petrella,Deborah Terry,Dale N. Gerding

Journal of clinical microbiology（2014）

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摘要

A commercial PCR assay of perirectal swab specimens detected 17 (68%) of 25 asymptomatic carriers of toxigenic Clostridium difficile, including 93% with skin and/or environmental contamination. A clinical prediction rule, followed by PCR screening, could be used to identify carriers at high risk of C. difficile shedding.

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