The GTPase-activating protein RN-tre controls focal adhesion turnover and cell migration.

Andrea Palamidessi,Emanuela Frittoli,Nadia Ducano,Nina Offenhauser,Sara Sigismund,Hiroaki Kajiho,Dario Parazzoli,Amanda Oldani,Marco Gobbi,Guido Serini,Pier Paolo Di Fiore,Giorgio Scita,Letizia Lanzetti

Current Biology（2013）

引用 53|浏览12

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摘要

•RN-tre localizes to focal adhesions•Genetic deletion of RN-tre increases the activity of Rab5•RN-tre controls β1 integrin endocytosis and turnover of focal adhesions•By negatively regulating Rab5 function, RN-tre restricts directed cell migration

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