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Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice

Luc Baeyens,Marie Lemper,Gunter Leuckx,Sofie De Groef,Paola Bonfanti,Geert Stangé,Ruth Shemer,Christoffer Nord,David W Scheel,Fong C Pan,Ulf Ahlgren,Guoqiang Gu,Doris A Stoffers,Yuval Dor,Jorge Ferrer,Gerard Gradwohl,Christopher V E Wright,Mark Van de Casteele,Michael S German,Luc Bouwens,Harry Heimberg

NATURE BIOTECHNOLOGY（2013）

引用 168|浏览22
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摘要
Short-term treatment with cytokines reprograms acinar cells into beta cells and restores durable normoglycemia in diabetic mice.
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关键词
cell differentiation,cell proliferation,ciliary neurotrophic factor,diabetes mellitus,differentiation,signal transduction
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