Effects of chronic glucagon-like peptide-2 therapy during weaning in neonatal pigs

David L. Sigalet,Elaine de Heuvel,Laurie Wallace,Estrella Bulloch,Justine Turner,Paul W. Wales,Patrick Nation,Pamela R. Wizzard,Bollette Hartmann,Meena Assad,Jens J. Holst

Regulatory Peptides（2014）

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摘要

•High doses of GLP-2 throughout the weaning period are well tolerated•GLP-2 effects in growing animals are confined to the intestinal mucosa•High doses of GLP-2 down-regulate the expression of the GLP-2 receptor•Exogenous GLP-2 does not affect stimulus response, or feed intake in infant pigs•GLP-2 pK after s.c. injection are similar in infant pigs and adult humans

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关键词

Nutrient absorption,Ki-67,Crypt cell proliferation,DPP-IV,Feeding behavior

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