Rapid induction of REDD1 gene expression in macrophages in response to stress-related catecholamines.

Yoshiki Yanagawa, Sachiko Hiraide,Machiko Matsumoto,Hiroko Togashi

Immunology Letters（2014）

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摘要

•REDD1 is characterized as a new host defense factor.•We examined effect of adrenaline and noradrenaline on macrophage expression of REDD1.•Adrenaline and noradrenaline upregulated REDD1 expression in macrophages.•β2-Adrenoceptor and cAMP appeared to be responsible for the REDD1 upregulation.

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关键词

Ab,Ad,AR,cAMP,Epac,GAPDH,IL,LPS,mTOR,mTORC1,NA,PCR,PKA,REDD1,RT,TNF

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