Sangivamycin induces apoptosis by suppressing Erk signaling in primary effusion lymphoma cells.

Kazufumi Wakao,Tadashi Watanabe,Tadatoshi Takadama,Sadaharu Ui,Zenpei Shigemi,Hiroki Kagawa,Chizuka Higashi,Rie Ohga,Takahiro Taira,Masahiro Fujimuro

Biochemical and Biophysical Research Communications（2014）

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摘要

•Sangivamycin induces the apoptosis of B cell lymphoma PEL cells.•Sangivamycin suppresses Erk signaling by inhibiting Erk phosphorylation in PEL cells.•The activation of Erk signaling is essential for PEL cell survival.•Sangivamycin induces the apoptosis of PEL cells without production of progeny virus.•Sangivamycin may serve as a novel drug for the treatment of PEL.

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KSHV,HHV-8,PEL

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