Salmonella vaccines: lessons from the mouse model or bad teaching?

•Invasive non-typhoidal salmonelloses (iNTS) are increasing.•Vaccines for iNTS will likely be different from those developed for typhoid fever.•Typhoid vaccines target antibodies against Vi antigen, or use an orally administered, live vaccine.•It is not clear whether the immune correlates of protection seen in mouse typhoid models will be useful in developing new iNTS vaccines.•Recent iterations of these models, with ‘humanisation’, may assist in identifying functional correlates of protection.