Overexpression of the dopamine D3 receptor in the rat dorsal striatum induces dyskinetic behaviors.

Samantha R Cote,Vineet C Chitravanshi,Carina Bleickardt,Hreday N Sapru,Eldo V Kuzhikandathil

Behavioural Brain Research（2014）

引用 31|浏览3

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摘要

•AAV-2 expressing D3 receptors effectively transduces neurons in rat striatum.•Ectopic expression of D3 receptor in rat striatum contributes to l-DOPA-induced dyskinesia.•D3 receptor tolerance property contributes to l-DOPA-induced dyskinesia.•Chronic l-DOPA treatment of rats overexpressing D3 receptor induces vacuous chewing.

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关键词

Parkinson's disease,Levodopa-induced dyskinesia,Dopamine receptor agonist,Tolerance,Adeno-associated virus

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