Identification of a methoxynaphthalene scaffold as a core replacement in quinolizidinone amide M(1) positive allosteric modulators.

Bioorganic & Medicinal Chemistry Letters（2014）

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摘要

A series of methoxynaphthalene amides were prepared and evaluated as alternatives to quinolizidinone amide M1 positive allosteric modulators.

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关键词

M1,Allosteric modulator,Muscarinic,Alzheimer’s disease,P-glycoprotein

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