Human coronavirus NL63 replication is cyclophilin A-dependent and inhibited by non-immunosuppressive cyclosporine A-derivatives including Alisporivir.

Javier Carbajo-Lozoya,Yue Ma-Lauer,Miroslav Malešević,Martin Theuerkorn,Viktoria Kahlert,Erik Prell,Brigitte von Brunn,Doreen Muth,Thomas F Baumert,Christian Drosten,Gunter Fischer,Albrecht von Brunn

Virus Research（2014）

引用 115|浏览42

暂无评分

摘要

•Cyclophilin A (CypA) is a host factor for human coronavirus NL63 replication.•CypA is a target for anti-coronaviral therapy.•Non-immunosuppressive CsA derivatives (Alisporivir, NIM811) inhibit CoV replication.•New classes of non-immunosuppressive CsA/FK506 derivatives inhibit CoV replication.

查看译文

关键词

EC50,CsA/CsD,PPIase,CypA/B,ALV,FKBP

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要