Apicoplast acetyl Co-A carboxylase of the human malaria parasite is not targeted by cyclohexanedione herbicides

Christopher D. Goodman,Vanessa Mollard,Theola Louie,Georgina A. Holloway,Keith G. Watson,Geoffrey I. McFadden

International Journal for Parasitology（2014）

引用 14|浏览5

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摘要

•Plasmodium falciparum acetyl-CoA carboxylase (PfACC) localises to the apicoplast.•PfACC is not essential for in vitro blood stage growth of P. falciparum.•ACC inhibiting herbicides kill parasites but not by targeting PfACC.

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关键词

Acetyl Co-A carboxylase,Apicoplast,Fatty acid biosynthesis,Herbicides,Malaria

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