Human IgE responses to different splice variants of Schistosoma mansoni tropomyosin: associations with immunity.

•Tropomyosin (Tpm) is a common IgE antigen in invertebrates.•Alternative splicing generates at least 13 Tpm isoforms in Schistosoma mansoni.•Four different isoforms of S. mansoni TpmII (SmTpmII.3, 4, 7 and 8) were expressed.•IgE and IgG4 responses to isoforms were measured in 228 S. mansoni-infected males.•IgE to SmTpmII.3 was associated with reduced re-infection 2years after treatment.