A quinazoline-derivative compound with PARP inhibitory effect suppresses hypertension-induced vascular alterations in spontaneously hypertensive rats.

Klara Magyar,Laszlo Deres,Krisztian Eros,Kitti Bruszt,Laszlo Seress,Janos Hamar,Kalman Hideg,Andras Balogh,Ferenc Gallyas,Balazs Sumegi,Kalman Toth,Robert Halmosi

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease（2014）

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摘要

•PARP-inhibitors protect against the development of hypertensive vascular remodeling.•PARP-1 inhibitors do not have blood pressure lowering effect.•The protective mechanism involves the inhibition of MAPKs via modulation of MKP-1.•The cytoprotective PI3K/Akt-1 signaling was activated.•Activation of the transcription factor NF-κB was also moderated by PARP inhibition.

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关键词

AngII,AIF,ASI,AP-1,ASK1,Crm1,DAB,DBP,DD,ERK,GSK-3β,4-HNE,JNK,MAPK,p38 MAPK,MKP-1,NADPH,NF-κB,PAR,PARP-1,PBS,PI-3 kinase,PKC,ROS,SBP,SD,SEM,SHR,STAT,TGF-β1,VEGF,WKY

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