MCM10: one tool for all-Integrity, maintenance and damage control.

•Mcm10 was identified as a suppressor of chromosome instability in independent genome-wide screens.•Mcm10 facilitates Cdc45:Mcm2-7:GINS helicase activation and interacts with multiple players at the replication fork.•The structure of Mcm10 reveals self-oligomerization, DNA binding and protein–protein interaction motifs.•Mcm10's genetic interaction network identifies pathways required for resistance to replication stress.•Dysregulation of Mcm10 in cancer suggests a potential role in tumorigenesis.