The discovery and SAR of cyclopenta[b]furans as inhibitors of CCR2.

Michael P Winters,Christopher A Teleha,Fu-An Kang,David McComsey,John C O'Neill,Cuifen Hou,Thomas Kirchner,Ping Wang,Dana Johnson,Zhihua Sui

Bioorganic & Medicinal Chemistry Letters（2014）

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摘要

The discovery of a novel series of cyclopenta[b]furans as CCR2 inhibitors is discussed. This series has excellent CCR2 potency and PK characteristics, and good cardiovascular safety.

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