Perineuronal nets and schizophrenia: the importance of neuronal coatings.

Neuroscience & Biobehavioral Reviews（2014）

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摘要

•Deficits in PNNs impair key brain maturational processes linked to schizophrenia.•Constituent elements of the PNN are dysregulated in patients with schizophrenia.•Poor structural integrity of PNNs may underlie the neural deficits in schizophrenia.•Restoring the integrity of PNNs may help rescue neurodevelopmental abnormalities.

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关键词

Perineuronal nets,Schizophrenia,Neurodevelopment,Parvalbumin,Synaptic plasticity,Synaptic connectivity,Neuronal protection

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