Activation of the MKL1/actin signaling pathway induces hormonal escape in estrogen-responsive breast cancer cell lines.

Gwenneg Kerdivel,Antoine Boudot,Denis Habauzit,Frederic Percevault,Florence Demay,Farzad Pakdel,Gilles Flouriot

Molecular and Cellular Endocrinology（2014）

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摘要

•MKL1 activity is enhanced in estrogen (E2)-independent breast cancer cell lines.•MKL1 activation in E2-dependent MCF-7 cells represses estrogen receptor expression.•MKL1 activation abolishes E2-dependent proliferation and transcription.•Growth factor signaling and E2-independent proliferation are enhanced by MKL1.•MKL1 activation result in hormonal escape and tamoxifen-resistance.

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关键词

MKL1,Hormone resistance,Breast cancer,Cell growth,Estrogen receptor,Tamoxifen

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