Discovery and SAR of novel tetrahydropyrrolo[3,4-c]pyrazoles as inhibitors of the N-type calcium channel.

Michael P Winters,Nalin Subasinghe,Mark Wall,Edward Beck,Michael R Brandt,Michael F A Finley,Yi Liu,Mary Lou Lubin,Michael P Neeper,Ning Qin,Christopher M Flores,Zhihua Sui

Bioorganic & Medicinal Chemistry Letters（2014）

引用 17|浏览15

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摘要

A novel series of substituted tetrahydropyrrolo[3,4-c]pyrazoles were investigated as blockers of the N-type calcium channel (Cav2.2 channels), a chronic pain target.

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关键词

Tetrahydropyrrolo[3,4-c]pyrazoles,N-type calcium channel,Cav2.2 blockers,Pain

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