Complete Genome Sequences Of Eight Helicobacter Pylori Strains With Different Virulence Factor Genotypes And Methylation Profiles, Isolated From Patients With Diverse Gastrointestinal Diseases On Okinawa Island, Japan, Determined Using Pacbio Single-Molecule Real-Time Technology

Kazuhito Satou,Akino Shiroma,Kuniko Teruya,Makiko Shimoji,Kazuma Nakano,Ayaka Juan,Hinako Tamotsu,Yasunobu Terabayashi,Misako Aoyama,Morimi Teruya,Rumiko Suzuki,Miyuki Matsuda,Akihiro Sekine,Nagisa Kinjo,Fukunori Kinjo,Yoshio Yamaoka,Takashi Hirano

MICROBIOLOGY RESOURCE ANNOUNCEMENTS（2014）

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摘要

We report the complete genome sequences of eight Helicobacter pylori strains isolated from patients with gastrointestinal diseases in Okinawa, Japan. Whole-genome sequencing and DNA methylation detection were performed using the PacBio platform. De novo assembly determined a single, complete contig for each strain. Furthermore, methylation analysis identified virulence factor genotype-dependent motifs.

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