Hepatic PPARγ and LXRα independently regulate lipid accumulation in the livers of genetically obese mice.

•The role of hepatic PPARγ in LXRα-associated fat accumulation was determined using mice lacking hepatic PPARγ.•The LXR-specific ligand T0901317 was administered to normal or obesity model mice lacking hepatic PPARγ.•The T0901317 increased development of fatty liver in mice lacking hepatic PPARγ.•Pathways involving LXRα and PPARγ independently accelerated its development.