Effect of docosahexaenoic acid on hippocampal neurons in high-glucose condition: involvement of PI3K/AKT/nuclear factor-κB-mediated inflammatory pathways.

R-H Yang,J Lin,X-H Hou,R Cao,F Yu,H-Q Liu,A-L Ji,X-N Xu,L Zhang,F Wang

Neuroscience（2014）

引用 32|浏览5

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摘要

•High glucose increases the lipid peroxidation of the cultured hippocampal neurons.•High glucose promotes the IKKβ/NF-κB activation and inflammatory level in neurons.•High glucose impairs insulin signaling by suppressing PI3K/AKT activities.•Docosahexaenoic acid prevents the neuron apoptosis induced by high glucose.

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关键词

AKT,DHA,DM,EDTA,ELISA,IKKβ,IL-6,MDA,MTT,NF-κB,PBS,PCR,PI3K,PUFAs,SDS,SOD,TNF-α

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