Original Design of Fluorescent Ligands by Fusing Bodipy and Melatonin Neurohormone

Jeremy Thireau,Justine Marteaux,Philippe Delagrange,Francois Lefoulon,Laurence Dufourny,Gerald Guillaumet,Franck Suzenet

ACS medicinal chemistry letters（2013）

引用 26|浏览4

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摘要

An original design and synthesis of fluorescent ligands for melatonin receptor studies is presented and consists in the fusion of the endogenous ligand with the fluorescent BODIPY core. Probes I-IV show high affinities for MT1 and MT2 melatonin receptors and exhibit fluorescence properties compatible with cell observation.

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关键词

GPCRs,melatonin,fluorescence,molecular probes,BODIPY

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