Pivotal Role of an Aliphatic Side Chain in the Development of an HDM2 Inhibitor.

Yao Ma,Brian R Lahue,Craig R Gibeau,Gerald W Shipps,Stéphane L Bogen,Yaolin Wang,Zhuyan Guo,Timothy J Guzi

ACS medicinal chemistry letters（2014）

引用 19|浏览20

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摘要

Introduction of an aliphatic side chain to a key position of a novel piperidine-based HDM2 inhibitor scaffold resulted in significant potency gains, enabling further series progression.

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关键词

HDM2,MDM2,p53,protein−protein interaction,small molecule inhibitor,substituted piperidine

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