Tetrameric ZBRK1 DNA binding domain has affinity towards cognate DNA in absence of zinc ions.

Lumbini R Yadav,Mahamaya N Biswal,Vikrant,M V Hosur,Ashok K Varma

Biochemical and Biophysical Research Communications（2014）

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摘要

•Purified ZBRK1-DBD forms a homotetramer like the transcription factor p53.•Surprisingly, it binds DNA in absence of zinc.•On binding with ZBRK1-DBD, DNA over winds.

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关键词

CD,ZBRK1,ZF

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