Effects of orexin 2 receptor activation on apnea in the C57BL/6J mouse.

Michael W Moore,Afaf Akladious,Yufen Hu,Sausan Azzam,Pingfu Feng,Kingman P Strohl

Respiratory Physiology & Neurobiology（2014）

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摘要

•The C57BL/6J mouse is a preclinical model for sleep apnea.•The C57BL/6J mouse is a preclinical model for apneas in sleep.•An orexin 2 receptor agonist reduces apnea in sleep as well as in wakefulness, independent of effects on sleep-wake state.•Results are a small step in the development of pharmacologic approaches to the treatment of apnea.

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关键词

Sleep apnea,Orexin 2 agonist,Mouse model,Orexin 2 antagonist,Receptors,Sleep disordered breathing

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