Genomic Stability: Boosting Cohesion Corrects CIN
Current Biology(2014)
摘要
Chromosomal instability is a driving force for heterogeneity within tumours. A recent study shows that boosting sister chromatid cohesion corrects chromosomal instability in pRB-deficient cancer cells. This key finding provides an important lead to make tumours more susceptible to anti-cancer drugs.
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