Engineering plasmonic nanorod arrays for colon cancer marker detection.
Biosensors and Bioelectronics(2015)
摘要
Engineering plasmonic nanomaterials or nanostructures towards ultrasensitive biosensing for disease markers or pathogens is of high importance. Here we demonstrate a systematic approach to tailor effective plasmonic nanorod arrays by combining both comprehensive numerical discrete dipole approximations (DDA) simulation and transmission spectroscopy experiments. The results indicate that 200×50nm nanorod arrays with 300×500nm period provide the highest figure of merit (FOM) of 2.4 and a sensitivity of 310nm/RIU. Furthermore, we demonstrate the use of nanorod arrays for the detection of single nucleotide polymorphism in codon 12 of the K-ras gene that are frequently occurring in early stages of colon cancer, with a sensitivity down to 10nM in the presence of 100-fold higher concentration of the homozygous genotypes. Our work shows significant potential of nanorod arrays towards point-of-care applications in diagnosis and clinical studies.
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关键词
Plasmonics,Nanorod array,Localized surface plasmon resonance,Biosensing,Discrete dipole approximation,Single nucleotide polymorphism
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