Synthesis and anticancer activity of (E)-2-benzothiazole hydrazones.

Eric B Lindgren,Monique A de Brito,Thatyana R A Vasconcelos,Manuel O de Moraes,Raquel C Montenegro,Julliane D Yoneda,Kátia Z Leal

European Journal of Medicinal Chemistry（2014）

引用 63|浏览6

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摘要

Benzothiazole hydrazones have been synthesized and evaluated for their in vitro antiproliferative activity against three human cancer cell lines: HL-60 (leukemia), MDAMB-435 (breast) and HCT-8 (colon). The good cytotoxicity for the three cancer cell lines and theoretical profile of compounds 3o and 3p pointed them as promising lead molecules for anticancer drug design.

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关键词

(E)-2-benzothiazoles,Hydrazones,Anticancer,Lipinski's rule of five

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