A Palladium-Catalyzed Three-Component-Coupling Strategy For The Differential Vicinal Diarylation Of Terminal 1,3-Dienes

A palladium-catalyzed intermolecular vicinal diarylation of terminal 1,3-dienes using aryldiazonium tetrafluoroborates and arylboronic acids is reported. Using this technology, two different arenes are regioselectively introduced in a vicinal fashion across the terminal alkene of a variety of terminal 1,3-dienes at ambient temperature. Through the action of a chiral bicyclo[2.2.2]octadienyl ligand at -20 degrees C, good enantioselectivity has also been achieved.