Bortezomib prevents the expression of MMP-13 and the degradation of collagen type 2 in human chondrocytes.

Weihua Hu,Weikai Zhang,Feng Li,Fengjing Guo,Anmin Chen

Biochemical and Biophysical Research Communications（2014）

引用 20|浏览6

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摘要

•Bortezomib suppresses the degradation of type II collagen induced by TNF-α.•Bortezomib inhibits the expression of MMP-13.•Bortezomib inhibits the expression of IRF-1 through blunting JAK2/STAT1 pathway.

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关键词

Osteoarthritis,Type II collagen,Matrix metalloproteinase-13,TNF-α,Interferon response factor-1 (IRF-1)

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