Gremlin-1 inhibits macrophage migration inhibitory factor-dependent monocyte function and survival

Iris I. Müller,Madhumita Chatterjee,Martina Schneider,Oliver Borst,Peter Seizer,Tanja Schönberger,Sebastian Vogel,Karin A.L. Müller,Tobias Geisler,Florian Lang,Harald Langer,Meinrad Gawaz

International Journal of Cardiology（2014）

引用 27|浏览7

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摘要

•Grem1 decreases MIF-dependent monocyte migration and adhesion in vitro.•Intravenous administration of Grem1 inhibits leukocyte adhesion in vivo.•Grem1 reduces MIF-induced differentiation of monocytes into macrophages.•Grem1 inhibits the anti-apoptotic impact of MIF on monocytes.

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关键词

Gremlin-1,MIF,Monocyte,Migration,Apoptosis

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