Intracellular Retention of the Extracellular Domain of the (pro)renin Receptor in Mammalian Cells
Bioscience, biotechnology, and biochemistry(2014)
摘要
As a component of the renin-angiotensin system, the (pro)renin receptor [(P)RR] activates prorenin along with intracellular signaling pathways. In this study, the glutathione S-transferase-fused extracellular domain of (P)RR expressed in mammalian cells was recovered in the detergent phase in detergent-based two-phase separation experiments, and intracellular localization was observed by immunocytochemistry, suggesting retention inside the cell through stable membrane association.
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关键词
(pro)renin receptor,ATP6AP2,extracellular domain,phase separation,glutathione S-transferase (GST)
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