Discoidin domain receptor 1 (DDR1) kinase as target for structure-based drug discovery.

Sandeepkumar Kothiwale,Corina M Borza,Edward W Lowe,Ambra Pozzi,Jens Meiler

Drug Discovery Today（2015）

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摘要

•DDR1 is a potential therapeutic target as it is implicated in organ fibrosis and several cancers.•DDR1 has a characteristic kinase domain containing several functionally conserved residues.•Homology modeling and docking studies of DDR1 demonstrates possibilities for computer aided drug discovery.

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